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KMID : 1039420170510020148
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Journal of Pathology and Translational Medicine
2017 Volume.51 No. 2 p.148 ~ p.151
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Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea
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Mostafa Abou El Ela
Mohamed El Komy
Hay Rania Abdel
Hegazy Rehab
Sharobim Amin
Rashed Laila Ahmed
Amr Khalda
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Abstract
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Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR.
Methods: Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction.
Results: This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001).
Conclusions: TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.
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KEYWORD
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Immunity, innate, Toll-like receptors, Reverse transcriptase polymerase chain reaction, Pityriasis rosea
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